InvaderPLUS

InvaderPlus^® improves the start-to-finish time for assays that incorporate this technology. Future products from Hologic may incorporate InvaderPlus.

InvaderPlus involves a PCR reaction, followed by an Invader reaction, in a closed, single-tube format. This sequential process combines PCR-based target amplification with subsequent signal amplification through Invader^® chemistry. Heat denaturation of Taq polymerase precedes the Invader reaction. The thermostable enzyme, Cleavase^®, survives the heat- denaturing step, allowing the Invader reaction to occur.²